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For religious use, see Entheogenic use of cannabis. The use of cannabis as medicine has not been rigorously tested due to production and governmental restrictions, resulting in limited clinical research to define the safety and efficacy of using cannabis to treat diseases.Synthetic cannabinoids are available for prescription use in some countries, such as dronabinol and nabilone.Tetrahydrocannabinol (THC), the principal psychoactive constituent of the cannabis plant, has low toxicity while the LD50 (dose of THC needed to kill 50% of tested rodents) is high.Acute effects may include anxiety and panic, impaired attention, and memory (while intoxicated), an increased risk of psychotic symptoms, and possibly increased risk of accidents if a person drives a motor vehicle while intoxicated.Although cannabis remains prohibited for any use at the federal level, the Rohrabacher–Farr amendment was enacted in December 2014, limiting the ability of federal law to be enforced in states where medical cannabis has been legalized.Many different cannabis strains are collectively called medical cannabis.Evidence is lacking for both efficacy and safety of cannabis and cannabinoids in treating patients with HIV/AIDS or for anorexia associated with AIDS.As of 2013, current studies suffer from effects of bias, small sample size, and lack of long-term data.

Evidence for causing these cancers is mixed concerning heavy, long-term use.Tolerance to these effects develops over a period of days or weeks.The amount of cannabis normally used for medicinal purposes is not believed to cause any permanent cognitive impairment in adults, though long-term treatment in adolescents should be weighed carefully as they are more susceptible to these impairments.According to the United States Department of Health and Human Services, there were 455,000 emergency room visits associated with cannabis use in 2011.These statistics include visits in which the patient was treated for a condition induced by or related to recent cannabis use.

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